Epigallocatechin-3-gallate protects rat brain mitochondria against cadmium-induced damage
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منابع مشابه
Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent apoptosis in human lens epithelial cells
PURPOSE Oxidative stress has long been recognized as an important mediator of apoptosis in lens epithelial cells and also plays an important role in the pathogenesis of cataracts. (-)-Epigallocatechin gallate (EGCG), the most abundant component in green tea, has potent antioxidant activity. The goals of this study were to determine the protective effect of EGCG against H(2)O(2)-induced apoptoti...
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متن کاملIntraperitoneal injection of (−)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina
PURPOSE (-)-epigallocatechin-3-gallate (EGCG), a major catechin component of green tea, is reported to delay or prevent certain forms of cancer, arthritis, cardiovascular disease, and neurodegenerative disorders. In this study, we determined if systemically administered EGCG could protect the retina against light damage (LD) in mice. METHODS BALB/cJ mice were treated with either EGCG or salin...
متن کامل(−)-Epigallocatechin-3-gallate (EGCG), a polyphenol, protects against sepsis-induced acute liver injury in rats
Sepsis is a significant public health problem and is one of the leading causes of death in critically ill patients admitted to the intensive care unit. Liver dysfunction occurs frequently in cases of sepsis. This study aims to investigate the protective effects of (−)-epigallocatechin-3-gallate (EGCG) on polymicrobial sepsis-induced acute liver injury and to explore the underlying mechanism. Se...
متن کاملEpigallocatechin-3-gallate ameliorates alcohol-induced cognitive dysfunctions and apoptotic neurodegeneration in the developing rat brain.
Clinical and experimental evidence has demonstrated that ethanol is a teratogen, and its consumption during pregnancy induces harmful effects on the developing fetus that leads to mental retardation and long-term cognitive and behavioural deficits in offspring. The brain growth spurt period is highly sensitive to the neurotoxic effects of ethanol and it corresponds to the last trimester in huma...
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ژورنال
عنوان ژورنال: Food and Chemical Toxicology
سال: 2011
ISSN: 0278-6915
DOI: 10.1016/j.fct.2011.07.006